Leveraging Mathematical Modeling to Quantify Pharmacokinetic and Pharmacodynamic Pathways: Equivalent Dose Metric
نویسندگان
چکیده
منابع مشابه
Population Pharmacokinetic and Pharmacodynamic Modeling
As we acquire experience with the clinical and pharmacokinetic behavior of a drug, it is very desirable to capture this experience and its related information in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The purpose of population modeling is thus to describe and capture o...
متن کاملDemonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib.
The goals of this investigation were to illustrate the use of pharmacokinetic (PK)/pharmacodynamic (PD) modeling strategies in drug development based on a multiple-dose study of gefitinib in a preclinical tumor model. Mice bearing s.c. LN229-wild-type epidermal growth factor receptor or LN229-EGFRvIII mutant (a sensitizing mutation) tumors were administered gefitinib at oral doses of either 55 ...
متن کاملPharmacokinetic–Pharmacodynamic Modeling and ICU Sedation
Unexplored Territories IN this issue of ANESTHESIOLOGY, Barr et al. make a useful contribution to our understanding of the clinical pharmacology of intensive care unit (ICU) sedation. It is estimated that approximately $1 billion is spent each year in the United States alone on drugs used for sedation in the ICU. Misuse of these drugs contributes to morbidity, mortality, and expense. Optimizati...
متن کاملPharmacokinetic-pharmacodynamic Modeling of Antihypertensive Drugse
Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimize drug therapy of hypertension. PK/PD modeling in clinical research could contribute in drug development and clinical practice in several aspects, including an evaluation of the efficacy and safety of antihypertensive agents, enhancement of information during the development process, identificat...
متن کاملPharmacokinetic-pharmacodynamic modeling of propofol in children.
BACKGROUND The aim of this study was to identify the best model to describe pharmacokinetics and pharmacodynamics in prepubertal children and therefore to calculate the corresponding pharmacodynamic parameters. In addition, and to confirm our method, a group of postpubertal subjects was also studied. METHODS Sixteen children (9.5 yr, range 6-12) and 13 adults (22 yr, range 13-35) were include...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2019
ISSN: 1664-042X
DOI: 10.3389/fphys.2019.00616